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Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis

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Published on: March 7, 2018

Plasmon Modulated Upconversion Biosensors.

Anara Molkenova¹, Hye Eun Choi², Jeong Min Park²

¹Institute of Advanced Organic Materials, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan 46241, Republic of Korea.

|March 29, 2023

Summary

Lanthanide-based upconversion nanoparticles (UCNPs) offer unique light conversion for biosensing. This review explores plasmon-modulated UCNPs to enhance NIR light harvesting and upconversion efficiency for improved biosensing sensitivity and speed.

Keywords:

biosensing fluorescence resonance energy transfer (FRET)gold nanoparticles (GNPs)plasmon modulated upconversion plasmon-enhanced upconversion plasmonic nanoparticles (PNPs)surface plasmon resonance (SPR)upconversion nanoparticles (UCNPs)upconversion quenching

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Published on: August 30, 2017

Area of Science:

Nanotechnology
Biomedical Engineering
Optical Physics

Background:

Lanthanide-based upconversion nanoparticles (UCNPs) convert near-infrared (NIR) light to visible light for biological applications.
UCNPs are valuable for background-free biorecognition and biosensing due to their unique luminescence.
A key challenge is maximizing NIR light absorption and upconversion efficiency for enhanced biosensing performance without tissue damage.

Purpose of the Study:

To provide an overview of recent advancements in plasmon-modulated upconversion nanoformulations.
To highlight achievements and challenges in developing UCNPs for biosensing applications.
To discuss strategies for improving NIR light harvesting and upconversion efficiencies.

Main Methods:

Review of current literature on plasmon-enhanced UCNPs.
Analysis of strategies for optimizing UCNP performance through plasmonic modulation.
Discussion of laser-assisted photoactivation techniques and their impact on biological tissues.

Main Results:

Plasmonic modulation significantly enhances NIR light harvesting and upconversion efficiency in UCNPs.
Optimized UCNPs demonstrate potential for faster response times and improved sensitivity in biosensing.
Various plasmonic strategies are being explored to overcome current limitations.

Conclusions:

Plasmon-modulated UCNPs represent a promising frontier for advanced biosensing.
Further research is needed to optimize efficiency and ensure biocompatibility for clinical applications.
Overcoming challenges in NIR light management is crucial for next-generation biosensors.