Label-Free Electrochemical Biosensor Platforms for Cancer Diagnosis: Recent Achievements and Challenges.
1Department of Chemistry, Gebze Technical University, 41400 Kocaeli, Turkey.
Biosensors
|March 29, 2023
Summary
Early cancer detection is crucial for effective treatment. This review highlights label-free electrochemical sensors using biosensing elements for accurate, rapid cancer diagnosis without complex labeling steps.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Oncology
Background:
- Cancer remains a leading global health challenge, often due to late diagnosis.
- Accurate and rapid cancer diagnosis is critical for successful therapeutic outcomes.
- Electrochemical techniques show promise for advancing cancer detection methods.
Purpose of the Study:
- To review label-free electrochemical sensor platforms for cancer diagnosis.
- To classify these platforms based on their recognition elements.
- To discuss recent advancements and current challenges in the field.
Main Methods:
- Focus on electrochemical sensor platforms.
- Utilize biosensing elements (nucleic acids, aptamers, antibodies) for high selectivity.
- Emphasize label-free detection strategies to avoid interference and complex protocols.
Main Results:
- Label-free electrochemical sensors offer sensitive and selective cancer detection.
- Biosensing elements provide specific recognition, enhancing diagnostic accuracy.
- Elimination of labeling steps simplifies protocols and reduces potential errors.
Conclusions:
- Label-free electrochemical biosensors represent a significant advancement in cancer diagnostics.
- Continued research in this area holds potential for improved early cancer detection.
- Addressing current challenges will further optimize these diagnostic platforms.
