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Updated: Aug 5, 2025

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Surface Plasmon Resonance (SPR) Sensor for Cancer Biomarker Detection.

Sreyashi Das¹, Ram Devireddy¹, Manas Ranjan Gartia¹

¹Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.

|March 29, 2023

Summary

This summary is machine-generated.

Surface plasmon resonance (SPR) offers a rapid, minimally invasive method for detecting cancer biomarkers. This technology advances early tumor detection and monitoring, improving patient outcomes.

Keywords:

biomarker biosensor cancer liquid biopsy surface plasmon resonance

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Published on: March 20, 2015

Area of Science:

Biomedical Engineering
Analytical Chemistry
Oncology

Background:

Biomarkers are crucial for early cancer detection and monitoring, offering cost-effective alternatives to direct outcome measurement.
Reliable, precise, and validated cancer biomarker assays are essential due to cancer's global health impact.
Biomarker-based detection promises enhanced molecular understanding and improved early cancer surveillance.

Purpose of the Study:

To review advancements in Surface Plasmon Resonance (SPR) biosensing technologies for cancer detection.
To highlight SPR's potential for point-of-care biomarker identification.
To emphasize SPR's role in tracking cancer progression and preventing relapse.

Main Methods:

Review of current literature on SPR biosensing applications in oncology.
Discussion of SPR's capability for rapid, less invasive screening of various circulating biomarkers.
Focus on SPR's advantages for point-of-care diagnostics.

Main Results:

SPR enables quick screening of circulating tumor DNA (ctDNA), microRNA (miRNA), circulating tumor cells (CTCs), lipids, and proteins.
SPR is advantageous for point-of-care biomarker identification.
SPR facilitates timely detection of tumor markers for monitoring cancer and preventing relapse.

Conclusions:

SPR biosensing represents a significant advancement for cancer biomarker detection.
The technology supports early diagnosis, disease monitoring, and relapse surveillance.
SPR holds promise for improving cancer care through accessible, rapid diagnostics.