Surface Plasmon Resonance (SPR) Sensor for Cancer Biomarker Detection

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Oncology

Background:

• Biomarkers are crucial for early cancer detection and monitoring, offering cost-effective alternatives to direct outcome measurement.
• Reliable, precise, and validated cancer biomarker assays are essential due to cancer's global health impact.
• Biomarker-based detection promises enhanced molecular understanding and improved early cancer surveillance.

Purpose of the Study:

• To review advancements in Surface Plasmon Resonance (SPR) biosensing technologies for cancer detection.
• To highlight SPR's potential for point-of-care biomarker identification.
• To emphasize SPR's role in tracking cancer progression and preventing relapse.

Main Methods:

• Review of current literature on SPR biosensing applications in oncology.
• Discussion of SPR's capability for rapid, less invasive screening of various circulating biomarkers.
• Focus on SPR's advantages for point-of-care diagnostics.

Main Results:

• SPR enables quick screening of circulating tumor DNA (ctDNA), microRNA (miRNA), circulating tumor cells (CTCs), lipids, and proteins.
• SPR is advantageous for point-of-care biomarker identification.
• SPR facilitates timely detection of tumor markers for monitoring cancer and preventing relapse.

Conclusions:

• SPR biosensing represents a significant advancement for cancer biomarker detection.
• The technology supports early diagnosis, disease monitoring, and relapse surveillance.
• SPR holds promise for improving cancer care through accessible, rapid diagnostics.