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Design of Polymeric Surfaces as Platforms for Streamlined Cancer Diagnostics in Liquid Biopsies.
Faezeh Ghorbanizamani1, Hichem Moulahoum1, Emine Guler Celik2,3
1Biochemistry Department, Faculty of Science, Ege University, Bornova, 35100 Izmir, Türkiye.
Biosensors
|March 29, 2023
Summary
Advanced polymer materials are revolutionizing minimally invasive cancer diagnosis using liquid biopsies. These polymers enhance biosensor sensitivity and specificity for detecting scarce tumor markers, improving cancer survival rates.
Area of Science:
- Polymer Chemistry
- Biomedical Engineering
- Oncology
Background:
- Minimally invasive cancer diagnosis is crucial for improving patient survival.
- Liquid biopsies, such as blood samples, offer a non-invasive method to detect cancer markers.
- Detecting scarce tumor markers in complex biological matrices presents significant challenges.
Purpose of the Study:
- To review the latest advances in polymer synthesis for minimally invasive cancer diagnosis.
- To explore the application of novel polymer structures in liquid biopsy analysis.
- To critically assess the role of polymer-based biosensors in oncology.
Main Methods:
- Review of recent developments in polymer chemistry, including molecularly imprinted polymers, branched polymers, nanopolymer composites, and hybrids.
- Analysis of how polymer structures enhance biosensor performance (affinity, binding, specificity).
- Examination of polymer-based signal amplification strategies for low-concentrated targets.
Main Results:
- Novel polymer structures significantly improve the performance of biosensors for liquid biopsies.
- Polymers enhance sensitivity, specificity, and signal amplification in cancer marker detection.
- Various polymer architectures offer tailored solutions for different diagnostic needs.
Conclusions:
- Polymer chemistry plays an essential role in advancing minimally invasive cancer diagnosis through enhanced liquid biopsy platforms.
- Polymer-based biosensors offer improved detection capabilities for early cancer diagnosis and monitoring.
- This technology is vital for the future of clinical biomedicine and oncology.
