Recent Advancements of LSPR Fiber-Optic Biosensing: Combination Methods, Structure, and Prospects

Area of Science:

• Nanotechnology
• Biomedical Engineering
• Analytical Chemistry

Background:

• Fiber-optic biosensors utilizing localized surface plasmon resonance (LSPR) offer label-free, real-time monitoring with excellent biocompatibility and stability.
• These sensors are crucial for environmental science, clinical medicine, disease diagnosis, and food safety.
• Recent advancements focus on detecting clinical disease markers, environmental toxins, and novel sensitization mechanisms.

Purpose of the Study:

• To review the working principles, structural classifications, and application fields of LSPR fiber-optic biosensors.
• To discuss the advantages and disadvantages of current and future LSPR fiber-optic biosensor technologies.
• To address the future development prospects of LSPR-based fiber-optic biosensors.

Main Methods:

• Review of existing literature on LSPR fiber-optic biosensors.
• Classification of sensors based on optical fiber structure: traditional, special shape, and specialty optical fibers.
• Analysis of working principles, sensing mechanisms, and application domains.

Main Results:

• LSPR fiber-optic biosensors demonstrate significant potential in various fields due to their inherent advantages.
• Sensor structures are categorized into three main types, each with distinct characteristics.
• The review highlights key advancements in detection capabilities and sensitization strategies.

Conclusions:

• LSPR fiber-optic biosensors are a rapidly evolving technology with broad applicability.
• Further research into novel sensitization mechanisms and structural designs will enhance sensor performance.
• The future development of these biosensors holds promise for improved diagnostics and environmental monitoring.