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Natural IgG Anti-F (ab')2 Autoantibody Activity in Children with Autism
Sylvie Tordjman1,2, Annaëlle Charrier2, Michel Kazatchkine3
1Integrative Neuroscience and Cognition Center (INCC), 75006 Paris, France.
Biomedicines
|March 29, 2023
Summary
Children with autism have significantly lower levels of natural IgG anti-F(ab')2 autoantibodies, which are linked to autism severity and may indicate immune self-recognition dysfunction in autism pathogenesis.
Area of Science:
- Neuroimmunology
- Autism Spectrum Disorder Research
- Autoimmune Disorders
Background:
- Autoimmune abnormalities are frequently observed in children with autism.
- Natural autoantibodies (NAAbs) are crucial for immune self-recognition.
Purpose of the Study:
- To investigate the presence and levels of NAAbs in children with autism.
- To explore the association between NAAbs and autism severity.
Main Methods:
- ELISA was used to measure NAAbs in the sera of 60 children with autism and 112 typically developing controls.
- Participants were matched for age, sex, and puberty status.
Main Results:
- Significantly lower serum titers of IgG anti-F(abuty)2 autoantibodies were found in children with autism compared to controls (p < 0.0001).
- Reduced IgG anti-F(abuty)2 levels were negatively correlated with autism severity (p = 0.0001) and IQ scores (p = 0.01).
Conclusions:
- This study reports, for the first time, reduced natural anti-F(abuty)2 autoantibody activity in autism.
- Findings suggest a potential role for impaired self-recognition mechanisms in autism pathogenesis, particularly in severe cases.
- The results support the hypothesis of an autoimmune component in autism and suggest avenues for future research and potential treatments.
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