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Updated: Aug 5, 2025

Characterization and Functional Prediction of Bacteria in Ovarian Tissues
Published on: October 23, 2021
Immune-Onco-Microbiome: A New Revolution for Gynecological Cancers
Chiara Di Tucci1, Ilaria De Vito2, Ludovico Muzii1
1Department of Maternal and Child Health and Urological Sciences, Sapienza University, 00161 Rome, Italy.
Abstract:
Despite significant advances in understanding the pathogenetic mechanisms underlying gynaecological cancers, these cancers still remain widespread. Recent research points to a possible link between microbiota and cancer, and the most recent attention is focusing on the relationship between the microbiome, the immune system, and cancer. The microbiome diversity can affect carcinogenesis and the patient's immune response, modulating the inflammatory cascade and the severity of adverse events. In this review, we presented the recent evidence regarding microbiome alterations in patients with gynaecological tumours to understand if the link that exists between microbiome, immunity, and cancer can guide the prophylactic, diagnostic, and therapeutic management of gynaecological cancers.
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