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Related Concept Videos

Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

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Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
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Gastritis-II: Pathophysiology01:17

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
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Barrett Esophagus-II: Clinical Manifestations and Management01:21

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239
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
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Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study.

Mohammad Sheikh-Ahmad1, Leonard Saiegh1,2, Anan Shalata1

  • 1Institute of Endocrinology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel.

Biomedicines
|March 29, 2023
PubMed
Summary

High gastrin levels predict recurrence in Type I gastric neuroendocrine neoplasms (gNENs). Lower Ki-67 index was also observed in recurrent gNENs, questioning its predictive value for this condition.

Keywords:
Ki-67 indexchromogranin Agastrinmitotic countrecurrencetype I gastric neuroendocrine neoplasm

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Area of Science:

  • Gastroenterology
  • Oncology
  • Endocrinology

Background:

  • Type I gastric neuroendocrine neoplasms (gNENs) are linked to atrophic gastritis.
  • These tumors have a high recurrence rate, necessitating frequent endoscopic surveillance.
  • Predicting recurrence is crucial for managing patient follow-up.

Purpose of the Study:

  • To identify clinical, pathological, and biochemical factors that predict local recurrence in Type I gNENs.
  • To investigate the role of serum gastrin and Ki-67 index in gNEN recurrence.

Main Methods:

  • Retrospective analysis of clinical, pathological, and biochemical data from 27 patients with Type I gNENs treated between 2006 and 2022.
  • Evaluation of tumor recurrence rates and correlation with various patient and tumor characteristics.
  • Statistical analysis to compare factors between recurrent and non-recurrent disease groups.

Main Results:

  • Tumor recurrence was observed in 48% of patients (13/27) after a median of 35 months.
  • Significantly higher serum gastrin levels were found in patients with recurrent disease (788 ng/L) compared to non-recurrent disease (394 ng/L; p=0.047).
  • A significantly lower Ki-67 index was noted in recurrent gNENs (1%) versus non-recurrent ones (3.5%; p=0.035).

Conclusions:

  • Elevated serum gastrin levels play a significant role in the pathogenesis of Type I gNEN recurrence.
  • The predictive value of the Ki-67 index for the clinical course of Type I gNENs remains debatable.
  • Further research is needed to elucidate the precise mechanisms driving gNEN recurrence and to refine predictive markers.