Related Experiment Video

Updated: Aug 5, 2025

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

4.7K

Dilated Cardiomyopathy: A Comprehensive Approach to Diagnosis and Risk Stratification

André Ferreira1, Vera Ferreira1, Miguel Marques Antunes1

  • 1Cardiology Service, Hospital Santa Marta, Centro Hospitalar Universitário de Lisboa Central, 1169-050 Lisbon, Portugal.

Biomedicines
|March 29, 2023
PubMed

Insights

Dilated cardiomyopathy (DCM) is a common heart failure cause. New imaging and genetic tests improve diagnosis and risk stratification for better patient outcomes.

Area of Science:

  • Cardiology
  • Genetics
  • Medical Imaging

Background:

  • Dilated cardiomyopathy (DCM) is a primary cause of non-ischemic heart failure with high mortality.
  • Early structural cardiac abnormalities and arrhythmogenic phenotypes present diagnostic challenges.
  • Current therapies have limited impact on DCM outcomes.

Purpose of the Study:

  • To propose a systematic approach for DCM evaluation.
  • To improve diagnostic pathways and arrhythmic risk stratification.
  • To integrate novel diagnostic tools for better clinical decision-making.

Main Methods:

  • Review of recent advancements in cardiac magnetic resonance (CMR) and genetic testing.
  • Focus on a structured approach to DCM diagnosis and risk assessment.
  • Integration of imaging and genetic data for clinical guidance.

Main Results:

  • Cardiac magnetic resonance and genetic testing offer new insights into DCM.
  • Improved diagnostic accuracy for differentiating DCM from similar conditions.
  • Enhanced identification of patients at high risk for arrhythmias and poor treatment response.

Conclusions:

  • A comprehensive diagnostic strategy incorporating advanced imaging and genetics is crucial for DCM.
  • Structured risk stratification aids in personalized treatment and improved patient outcomes.
  • Novel approaches are essential for managing the complexities of dilated cardiomyopathy.

Keywords:
arrhythmogenic left ventricle cardiomyopathycardiovascular magnetic resonancedilated cardiomyopathygenetic testingreverse remodellingrisk stratification

More Related Videos

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.2K
Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

16.1K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
14
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
20
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
18
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
26
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
14
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
23