Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Karyotyping01:17

Karyotyping

62.0K
Overview
62.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral Measurable Residual Disease Activity Assessment by MALDI-TOF Mass Spectrometry in Patients With Newly Diagnosed Multiple Myeloma in the Phase III GMMG-HD7 Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

How to talk about death? A cross-sectional survey on patients', informal caregivers' and health care professionals' views in the setting of allogenic hematopoietic stem cell transplantation.

Annals of hematology·2026
Same author

The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease.

Brain pathology (Zurich, Switzerland)·2026
Same author

Loss-of-function variants in the CAPN1 activator CD99L2 cause X-linked spastic ataxia.

Nature communications·2026
Same author

Results of brexucabtagene-autoleucel for patients with relapsed/refractory Mantle Cell Lymphoma in the routine setting in Germany and Switzerland.

Bone marrow transplantation·2026
Same author

Prevention of ubiquitination at K6 and K9 in mutant huntingtin exacerbates disease pathology in a knock-in mouse model.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: Aug 5, 2025

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.1K

Optical Genome Mapping for Cytogenetic Diagnostics in AML.

Verena Nilius-Eliliwi1, Wanda M Gerding2, Roland Schroers1

  • 1Center for Hemato-Oncological Diseases, Department of Medicine, University Hospital Knappschaftskrankenhaus Bochum, Ruhr-University Bochum, 44892 Bochum, Germany.

Cancers
|March 29, 2023
PubMed
Summary
This summary is machine-generated.

Optical Genome Mapping (OGM) offers unbiased, genome-wide detection of structural variants crucial for acute myeloid leukemia (AML) diagnostics. This review explores OGM

Keywords:
AMLOptical Genome MappingWGScytogeneticswhole-genome sequencing

More Related Videos

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
06:25

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

Published on: February 6, 2012

18.9K
Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
07:53

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

Published on: April 15, 2022

4.3K

Related Experiment Videos

Last Updated: Aug 5, 2025

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.1K
Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
06:25

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

Published on: February 6, 2012

18.9K
Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
07:53

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

Published on: April 15, 2022

4.3K

Area of Science:

  • Genomics
  • Hematology
  • Cancer Diagnostics

Background:

  • Acute myeloid leukemia (AML) classification relies on genetic diagnostics.
  • Structural variants are key aberrations in AML, beyond single-nucleotide variants.

Purpose of the Study:

  • To review the current knowledge of Optical Genome Mapping (OGM) for hematological malignancies, specifically AML.
  • To assess OGM's potential to enhance and possibly replace existing cytogenetic diagnostic techniques in AML.
  • To compare OGM with amplification-based methods and provide future outlook.

Main Methods:

  • Review of current literature on Optical Genome Mapping (OGM).
  • Focus on OGM's application in diagnosing hematological malignancies, particularly AML.
  • Comparative analysis of OGM against traditional cytogenetic methods and amplification-based techniques.

Main Results:

  • OGM is an unbiased, genome-wide, amplification-free method for detecting structural variants.
  • OGM shows potential to expand cytogenetic diagnostics in AML.
  • OGM may replace older techniques like chromosomal-banding analysis, FISH, and CNV microarrays.

Conclusions:

  • OGM is a promising technology for AML diagnostics, offering comprehensive structural variant detection.
  • OGM has the potential to advance cytogenetic analysis in AML, possibly supplanting conventional methods.
  • Further research and validation are needed to fully integrate OGM into routine AML diagnostics.