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Prevention and Treatment of HPV-Induced Skin Tumors

Daniel Hasche1, Baki Akgül2

  • 1Division of Viral Transformation Mechanisms, Research Program "Infection, Inflammation and Cancer", German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.

Cancers
|March 29, 2023
PubMed

Insights

Non-melanoma skin cancer is common, and beta human papillomavirus (betaHPV) infections are linked to its development. This review covers advances in betaHPV vaccines for prevention and treatment.

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Non-melanoma skin cancer (NMSC) is the most prevalent human cancer, with rising incidence rates.
  • Emerging evidence links beta human papillomavirus (betaHPV) skin infections to the development of cutaneous squamous cell carcinomas (cSCCs).

Purpose of the Study:

  • To review current advancements in the development of prophylactic and therapeutic vaccines targeting betaHPV.
  • To summarize progress in preclinical and clinical research for betaHPV vaccines.

Main Methods:

  • Literature review of scientific publications on betaHPV and skin cancer.
  • Analysis of preclinical data and clinical trial outcomes for betaHPV vaccines.

Main Results:

  • The association between betaHPV and cSCCs highlights the potential for vaccine development.
  • Significant progress has been made in preclinical testing of betaHPV vaccines.
  • Early-stage clinical trials are underway to evaluate the safety and efficacy of these vaccines.

Conclusions:

  • Vaccines against betaHPV represent a promising strategy for preventing and treating NMSC.
  • Continued research and clinical trials are crucial for the successful development of betaHPV vaccines.
Keywords:
HPVNMSCcSCCpapillomavirusesvaccination

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