Exercise Intervention for Bone Metastasis: Safety, Efficacy and Method of Delivery

Area of Science:

• Oncology
• Exercise Science
• Rehabilitation Medicine

Background:

• Exercise benefits are established for cancer patients.
• Bone metastases patients underutilize exercise due to safety, efficacy, and delivery concerns.
• Scoping review examines barriers to exercise in bone metastases patients.

Purpose of the Study:

• To explore barriers to exercise for patients with bone metastases.
• To review clinical trial data on exercise interventions for bone metastases.
• To assess the safety and efficacy of exercise in this population.

Main Methods:

• Comprehensive literature search across major databases (PubMed, Scopus, etc.).
• Inclusion of trials with exercise interventions for bone metastases patients.
• Data analysis following PRISMA-ScR guidelines.

Main Results:

• 26 trials reviewed, including aerobic and resistance training.
• Low incidence of serious adverse events (3), unrelated to bone metastases.
• High compliance (80.3%) with remote exercise delivery.
• Exercise improves functional capacity, strength, lean mass, and cardiovascular function.
• Exercise is safe for bone metastases patients regardless of delivery method.

Conclusions:

• Exercise therapy is safe and effective for patients with bone metastases.
• Both in-person and remote delivery methods are viable.
• Exercise can be safely integrated into adjuvant cancer therapy for bone metastases.