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Updated: Aug 5, 2025

Deep Learning-Based Segmentation of Cryo-Electron Tomograms
Published on: November 11, 2022
Implicit Solutions of the Electrical Impedance Tomography Inverse Problem in the Continuous Domain with Deep Neural
Thilo Strauss1, Taufiquar Khan2
1Research Department at ETAS GmbH, Robert Bosch GmbH, 70469 Stuttgart, Germany.
Abstract:
Electrical impedance tomography (EIT) is a non-invasive imaging modality used for estimating the conductivity of an object Ω from boundary electrode measurements. In recent years, researchers achieved substantial progress in analytical and numerical methods for the EIT inverse problem. Despite the success, numerical instability is still a major hurdle due to many factors, including the discretization error of the problem. Furthermore, most algorithms with good performance are relatively time consuming and do not allow real-time applications. In our approach, the goal is to separate the unknown conductivity into two regions, namely the region of homogeneous background conductivity and the region of non-homogeneous conductivity. Therefore, we pose and solve the problem of shape reconstruction using machine learning. We propose a novel and simple jet intriguing neural network architecture capable of solving the EIT inverse problem. It addresses previous difficulties, including instability, and is easily adaptable to other ill-posed coefficient inverse problems. That is, the proposed model estimates the probability for a point of whether the conductivity belongs to the background region or to the non-homogeneous region on the continuous space Rd∩Ω with d∈{2,3}. The proposed model does not make assumptions about the forward model and allows for solving the inverse problem in real time. The proposed machine learning approach for shape reconstruction is also used to improve gradient-based methods for estimating the unknown conductivity. In this paper, we propose a piece-wise constant reconstruction method that is novel in the inverse problem setting but inspired by recent approaches from the 3D vision community. We also extend this method into a novel constrained reconstruction method. We present extensive numerical experiments to show the performance of the architecture and compare the proposed method with previous analytic algorithms, mainly the monotonicity-based shape reconstruction algorithm and iteratively regularized Gauss-Newton method.
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