Emergency Department Visits in Children Associated with Exposure to Ambient PM1 within Several Hours
Yachen Li1, Lifeng Zhu1, Yaqi Wang1
1Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Institute of Social Development and Health Management, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China.
Insights
Short-term exposure to fine particulate matter (PM1 and PM2.5) significantly increases pediatric emergency department visits (PEDVs). A higher PM1/PM2.5 ratio indicates additional risk, emphasizing the need to reduce PM1 for children's health.
Area of Science:
- Environmental Health
- Pediatric Health
- Air Quality Monitoring
Background:
- Emerging evidence links short-term exposure to fine particulate matter (PM1) with increased pediatric morbidity and mortality.
- Most studies analyze daily pollution levels, neglecting crucial intra-day exposure variations.
Purpose of the Study:
- To investigate the association between intra-day exposures to PM1 and PM2.5 and pediatric emergency department visits (PEDVs).
- To determine if a high PM1/PM2.5 ratio elevates PEDV risk independently of short-term PM2.5 exposure.
Main Methods:
- Collected hourly data on PM1, PM2.5 concentrations, PEDVs, and meteorological factors in Guangzhou and Shenzhen (2015-2016).
- Employed time-stratified case-crossover design and conditional logistic regression to assess associations at various lag hours.
- Quantified PM1's contribution to PM2.5-associated risk using the PM1/PM2.5 ratio, adjusting for PM2.5.
Main Results:
- Both PM1 and PM2.5 exposures within hours were significantly associated with increased PEDVs.
- Each interquartile range increase in PM1 raised PEDV risk by 3.9% in Guangzhou and 3.2% in Shenzhen (lag 0-3 h).
- A high PM1/PM2.5 ratio correlated with elevated PEDVs, showing excess risks of 2.6% (Guangzhou, lag 73-96 h) and 1.2% (Shenzhen, lag 0-3 h).
- Stronger PM-PEDV relationships were observed during colder months.
Conclusions:
- Short-term exposure to ambient PM1 and PM2.5 is linked to increased pediatric emergency visits.
- A high PM1/PM2.5 ratio may pose an additional risk beyond PM2.5's short-term effects.
- Reducing PM1 is crucial for mitigating health risks associated with PM2.5 exposure in children.
Background:
Emerging evidence has integrated short-term exposure to PM1 with children's morbidity and mortality. Nevertheless, most available studies have been conducted on a daily scale, ignoring the exposure variations over the span of a day.
Objective:
The main intention of this study was to examine the association between pediatric emergency department visits (PEDVs) and intra-day exposures to PM1 and PM2.5. We also aimed to investigate whether a high PM1/PM2.5 ratio elevated the risk of PEDVs independent from PM2.5 exposure within several hours.
Methods:
We collected hourly data on aerial PM1 and PM2.5 concentrations, all-cause PEDVs, and meteorological factors from two megacities (i.e., Guangzhou and Shenzhen) in southern China during 2015-2016. Time-stratified case-crossover design and conditional logistic regression analysis were used to assess the associations of PEDVs with exposures to PM1 and PM2.5 at different lag hours. The contribution of PM1 to PM2.5-associated risk was quantified by introducing PM1/PM2.5 ratio as an additional exposure indicator in the analysis adjusting for PM2.5. Subgroup analyses were performed stratified by sex, age, and season.
Results:
During this study period, 97,508 and 101,639 children were included from Guangzhou and Shenzhen, respectively. PM1 and PM2.5 exposures within several hours were both remarkably related to an increased risk of PEDVs. Risks for PEDVs increased by 3.9% (95% confidence interval [CI]: 2.7-5.0%) in Guangzhou and 3.2% (95% CI: 1.9-4.4%) in Shenzhen for each interquartile range (Guangzhou: 21.4 μg/m3, Shenzhen: 15.9 μg/m3) increase in PM1 at lag 0-3 h, respectively. A high PM1/PM2.5 ratio was substantially correlated with increased PEDVs, with an excess risk of 2.6% (95% CI: 1.2-4.0%) at lag 73-96 h in Guangzhou and 1.2% (95% CI: 0.4-2.0%) at lag 0-3 h in Shenzhen. Stratified analysis showed a clear seasonal pattern in PM-PEDVs relationships, with notably stronger risks in cold months (October to March of the following year) than in warm months (April to September).
Conclusions:
Exposures to ambient PM1 and PM2.5 within several hours were related to increased PEDVs. A high PM1/PM2.5 ratio may contribute an additional risk independent from the short-term impacts of PM2.5. These findings highlighted the significance of reducing PM1 in minimizing health risks due to PM2.5 exposure in children.
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