Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular mechanisms of coronary microembolization-induced MINOCA.

Basic research in cardiology·2026
Same author

Reply: Strengths and Limitations of the Renal Locoregional Perfusion Platform.

JACC. Basic to translational science·2026
Same author

Quality of life in women and men after coronary artery bypass surgery.

JTCVS open·2026
Same author

Small Diameter Vascular Grafts Made in Minutes.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Reply: Hydrodissection for conduit harvesting: Catch the wave!

JTCVS open·2026
Same author

Cardiovascular stent technologies for coronary and valvular heart disease: the potential of 3D printing for stent fabrication.

Nature reviews. Cardiology·2026

Related Experiment Video

Updated: Aug 5, 2025

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

5.0K

Advances in 3D Organoid Models for Stem Cell-Based Cardiac Regeneration.

Marcy Martin1, Eric K N Gähwiler1, Melanie Generali1

  • 1Institute for Regenerative Medicine (IREM), University of Zurich, 8952 Schlieren, Switzerland.

International Journal of Molecular Sciences
|March 29, 2023
PubMed
Summary

Adult heart regeneration remains a challenge. Stem cell therapies and 3D cardiac organoids show promise for improving cardiac repair and disease modeling, advancing regenerative medicine.

Keywords:
cardiac organoidscardiac regenerationengineered heart tissuepluripotent stem cellsprecision medicine

More Related Videos

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells
10:37

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

6.6K
Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues
12:28

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

2.6K

Related Experiment Videos

Last Updated: Aug 5, 2025

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

5.0K
Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells
10:37

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

6.6K
Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues
12:28

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

2.6K

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Biology
  • Stem Cell Technology

Background:

  • The adult human heart has limited capacity for regeneration after injury, representing a significant clinical challenge.
  • Current treatments focus on mitigating ischemic damage but cannot restore lost cardiac function or stimulate cardiomyocyte proliferation.
  • Pluripotent stem cell technologies and advanced 3D culture systems offer new avenues for cardiac repair and disease modeling.

Purpose of the Study:

  • To review current advancements and limitations in stem cell-based cardiac regenerative medicine.
  • To discuss the clinical applications and challenges of stem cell therapies and ongoing clinical trials.
  • To explore the potential of 3D cardiac organoids for disease modeling, genetic screening, and understanding cardiac regeneration.

Main Methods:

  • Review of current literature on stem cell-based cardiac regeneration.
  • Analysis of clinical trial data and limitations of stem cell technologies.
  • Discussion of 3D cardiac organoid development and their application in disease modeling and regenerative research.

Main Results:

  • Stem cell-based therapies are progressing, but clinical translation faces hurdles.
  • 3D cardiac organoids provide a more accurate in vitro model of the human heart microenvironment.
  • Cardiac organoids offer valuable insights into cardiac regeneration mechanisms and potential therapeutic strategies.

Conclusions:

  • Stem cell-based approaches and cardiac organoids hold significant potential for advancing cardiac regenerative medicine.
  • Further research and clinical trials are necessary to overcome limitations and translate these technologies into effective patient treatments.
  • 3D cardiac organoids represent a powerful tool for personalized medicine, disease modeling, and drug discovery in cardiology.