Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pullulan-dextran composite beads as bone fillers: from material design and industrial production to clinical application in oral surgery.

Frontiers in bioengineering and biotechnology·2026
Same author

SHEDs and BMSCs exhibit distinct lineage preferences in HUVECs dynamic spheroid co-cultures: vascular versus osteogenic commitment.

Bioengineering & translational medicine·2026
Same author

How the Hydrogel Scaffold's Porous Structure and Composition Control the Formation of Spheroids for Bone Tissue Engineering.

ACS biomaterials science & engineering·2026
Same author

Non-use of antenatal mental health care among women who self-reported having psychological difficulties during pregnancy: 2010-2021 prevalence trend and associated factors in 2021: A nationwide population-based study.

Journal of affective disorders·2026
Same author

A neurovascularized bone regeneration strategy for mandibular and alveolar bone defects based on elastin-like biomaterials.

Regenerative biomaterials·2026
Same author

Hybrid Polysaccharide/Magnetite Microgels for Drug-Free Magnetically Targeted Photothermal Thrombolysis.

Advanced healthcare materials·2026

Related Experiment Video

Updated: Aug 5, 2025

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
06:38

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis

Published on: October 12, 2016

10.1K

Bone Regeneration in Small and Large Segmental Bone Defect Models after Radiotherapy Using Injectable Polymer-Based

Camille Ehret1,2, Rachida Aid3,4, Bruno Paiva Dos Santos1

  • 1INSERM U1026, Tissue Bioengineering, University of Bordeaux, 33076 Bordeaux, France.

International Journal of Molecular Sciences
|March 29, 2023
PubMed
Summary

Strontium-doped microbeads enhance bone regeneration and vascularization, particularly in irradiated bone defects. This study shows strontium

Keywords:
bone reconstructionirradiated bone tissuestrontium-doped composite polymervascularization

More Related Videos

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

12.7K
A Reliable and Reproducible Critical-Sized Segmental Femoral Defect Model in Rats Stabilized with a Custom External Fixator
08:20

A Reliable and Reproducible Critical-Sized Segmental Femoral Defect Model in Rats Stabilized with a Custom External Fixator

Published on: March 24, 2019

8.7K

Related Experiment Videos

Last Updated: Aug 5, 2025

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
06:38

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis

Published on: October 12, 2016

10.1K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

12.7K
A Reliable and Reproducible Critical-Sized Segmental Femoral Defect Model in Rats Stabilized with a Custom External Fixator
08:20

A Reliable and Reproducible Critical-Sized Segmental Femoral Defect Model in Rats Stabilized with a Custom External Fixator

Published on: March 24, 2019

8.7K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Bone reconstruction after tumor removal and radiotherapy is difficult.
  • Polysaccharide-based microbeads with hydroxyapatite (HA) show osteoconductivity and osteoinductivity.
  • New composite microbeads with strontium (Sr)-doped HA particles were developed to improve biological performance.

Purpose of the Study:

  • To evaluate the efficacy of Sr-doped microbeads in preclinical bone defect models.
  • To assess the impact of strontium on bone formation, vascularization, and regeneration after irradiation.

Main Methods:

  • Characterization of Sr-doped microbeads (8% and 50% Sr) using microscopy, particle size analysis, and phosphorus content.
  • Implantation into rat femoral condyle and critical-size segmental bone defect models.
  • Histological and immunohistochemical analyses to evaluate bone regeneration and vascularization.

Main Results:

  • Sr-doped microbeads (8% and 50%) stimulated bone formation and vascularization in femoral condyle defects.
  • In irradiated segmental bone defects, 8% Sr-doped microbeads significantly enhanced vascularization and new vessel formation.
  • No significant differences in bone regeneration were observed between non-doped and Sr-doped microbeads in non-irradiated sites.

Conclusions:

  • Strontium-doped microbeads show potential for improving bone regeneration, especially vascularization in irradiated bone.
  • The 8% Sr substitution level appears optimal for enhancing vascularization in critical-size bone defects post-irradiation.
  • These findings suggest Sr-doped matrices can stimulate vascularization crucial for bone tissue regeneration after radiation therapy.