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Metabolic Reprogramming and Potential Therapeutic Targets in Lymphoma
Yuyang Pang1,2, Tingxun Lu1,3, Zijun Y Xu-Monette1,3
1Division of Hematopathology, Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.
International Journal of Molecular Sciences
|March 29, 2023
Summary
Lymphoma cells reprogram metabolism for proliferation, impacting disease progression and treatment. Targeting these metabolic pathways offers potential for novel lymphoma therapies.
Area of Science:
- Oncology
- Metabolic Pathways
- Cancer Biology
Background:
- Lymphoma is a complex disease driven by altered cellular metabolism.
- Aberrant metabolic pathways, including glucose, amino acid, and lipid metabolism, are crucial for lymphoma cell proliferation, survival, and drug resistance.
Purpose of the Study:
- To systematically review metabolic reprogramming in lymphoma.
- To highlight the role of metabolic enzymes, oncometabolites, and biomarkers in lymphomagenesis and progression.
- To discuss potential therapeutic strategies targeting metabolic pathways in lymphoma.
Main Methods:
- Literature review of current studies on lymphoma metabolism.
- Focus on glucose, amino acid, and lipid metabolism disorders.
- Analysis of metabolic pathway dysregulation, oncometabolites, and biomarkers.
Main Results:
- Lymphoma cells exhibit high glucose uptake, altered glycolysis, and increased glutamine and fatty acid metabolism.
- Metabolic reprogramming is influenced by genetic, epigenetic, and microenvironmental factors, including viral infections.
- Specific metabolic enzymes and metabolites are implicated in lymphoma development and progression.
Conclusions:
- Metabolic reprogramming is a hallmark of lymphoma, contributing to tumorigenesis and therapeutic resistance.
- Metabolic pathways and biomarkers hold promise for lymphoma diagnosis, characterization, and treatment.
- Targeting metabolic vulnerabilities presents a promising avenue for future lymphoma therapies.
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