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Genetic/Protein Association of Atopic Dermatitis and Tooth Agenesis
Wanlu Ouyang1, Charlene E Goh2, Wei Bo Ng3
1Department of Orthodontics, Shanghai Xuhui District Dental Disease Prevention and Control Institute, No. 500, Fenglin Road, Shanghai 200032, China.
International Journal of Molecular Sciences
|March 29, 2023
Summary
Atopic dermatitis and tooth agenesis share common genetic pathways. This review explores their links, finding a novel association between Wnt/β-catenin signaling and desmosomal proteins, suggesting shared developmental mechanisms.
Area of Science:
- Genetics and Developmental Biology
- Dermatology and Oral Health
Background:
- Atopic dermatitis (AD) and dental anomalies like tooth agenesis (TA) co-occur in some patients.
- A shared genetic and protein interaction pathway is hypothesized to underlie this association.
Purpose of the Study:
- To review key genes and signaling pathways in AD and TA.
- To identify potential associations between AD and TA.
- To analyze protein-protein interactions for novel pathway discoveries.
Main Methods:
- Literature review of genes and pathways in atopic dermatitis and tooth agenesis.
- Protein-protein interaction network analysis using the STRING database.
- Identification of common genes associated with both conditions.
Main Results:
- Key gene mutations and signaling pathways for AD and TA were described.
- A novel association was identified between the Wnt/β-catenin pathway (for TA) and desmosomal proteins (for AD).
- These proteins are crucial components of the skin barrier and tooth development.
Conclusions:
- The Wnt/β-catenin and desmosomal protein pathways represent a potential link between atopic dermatitis and tooth agenesis.
- Further research is warranted to elucidate the specific mechanisms driving the co-occurrence of these conditions.
- Understanding these shared pathways could lead to novel therapeutic strategies.
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