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Hidden Comorbidities in Asthma: A Perspective for a Personalized Approach
Matteo Maule1, Bianca Olivieri1, Gabriella Guarnieri2
1Allergy Unit and Asthma Center, Verona University Hospital, 37134 Verona, Italy.
Journal of Clinical Medicine
|March 29, 2023
Summary
Asthma often co-occurs with other systemic conditions beyond respiratory issues. Understanding these links is key for better patient management and personalized medicine approaches.
Area of Science:
- Pulmonology and Immunology
- Systemic Inflammatory Diseases
Background:
- Bronchial asthma is a prevalent global airway inflammatory disease.
- Asthma frequently presents with comorbidities impacting lung and non-lung systems.
- These comorbidities significantly increase the overall burden of asthma.
Purpose of the Study:
- To review recent findings on systemic conditions associated with asthma.
- To explore pathobiological interactions and shared immunological backgrounds between asthma and other diseases.
- To highlight the importance of considering these comorbidities in asthma care.
Main Methods:
- Literature review of recent research on asthma comorbidities.
- Analysis of pathobiological and immunological interactions.
- Synthesis of evidence regarding systemic conditions linked to asthma.
Main Results:
- Asthma shares bidirectional relationships with cardiovascular, metabolic, and neurodegenerative diseases.
- Rare disorders like sickle cell disease, alpha1-Antitrypsin deficiency, and hypereosinophilic conditions are linked to asthma.
- Shared immunological pathways underlie asthma and various systemic conditions.
Conclusions:
- Recognizing asthma's systemic comorbidities is crucial for comprehensive patient assessment.
- Integrating knowledge of these comorbidities can lead to improved diagnostic work-ups and long-term management strategies.
- This understanding supports a personalized medicine approach to asthma treatment.
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