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Bowman Layer Transplantation for Treating Keratoconus-Preliminary Findings.
Eline Elodie Barbara De Clerck1,2, Giorgio Enrico Bravetti1,2, Martina Kropp1,2
1Division of Ophthalmology, Department of Clinical Neurosciences, Geneva University Hospitals, 1205 Geneva, Switzerland.
Journal of Clinical Medicine
|March 29, 2023
Summary
Bowman layer transplantation effectively reduces and stabilizes corneal ectasia in advanced keratoconus patients. This surgical technique shows promising safety and efficacy, with significant keratometry improvements one year post-procedure.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Regenerative Medicine
Background:
- Keratoconus is a progressive corneal ectasia causing visual impairment.
- Mid-stromal isolated Bowman layer transplantation is an emerging surgical approach.
- This technique aims to reduce and stabilize corneal ectasia in advanced cases.
Purpose of the Study:
- To evaluate the effectiveness of Bowman layer transplantation.
- To assess the safety profile of this novel surgical technique.
- To analyze outcomes in patients with advanced, progressive keratoconus.
Main Methods:
- Systematic review adhering to PRISMA guidelines.
- Searched Medline, Cochrane Controlled Trials Register, and Embase.
- Included eight studies with 106 patients (120 eyes).
Main Results:
- Significant reduction in simulated and maximum keratometry at 1 month and 1 year post-transplantation.
- Low complication rates: 3% intraoperative and 9% postoperative.
- Estimated 75-85% success rate by experienced surgeons at 5-8 years.
Conclusions:
- Bowman layer transplantation appears to be an effective and safe treatment for advanced keratoconus.
- The procedure demonstrates significant visual stabilization and ectasia reduction.
- Further multicenter prospective studies are required to validate these findings.
