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Updated: Aug 5, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
Emergence from General Anaesthesia: Can We Discriminate between Emergence Delirium and Postoperative Pain?
Marta Somaini1,2, Thomas Engelhardt3, Pablo Ingelmo3,4,5,6
1Department of Anesthesia, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milano, Italy.
Insights
Unsettled behaviors after pediatric anesthesia, including emergence delirium (ED) and pain, are common. Differentiating these conditions is challenging, impacting treatment decisions and potentially leading to undertreatment or overtreatment.
Area of Science:
- Pediatric Anesthesiology
- Neuroscience
- Pain Management
Background:
- Unsettled behaviors occur in up to 80% of pediatric cases post-general anesthesia.
- Emergence delirium (ED) and acute pain are primary contributors to these behaviors.
- Challenges exist in defining and measuring unsettled behaviors, hindering guideline implementation.
Purpose of the Study:
- To review current knowledge on identifying and treating emergence delirium (ED) and acute pain in children.
- To provide a practical approach for managing these conditions in clinical practice.
- To address the difficulties in differentiating ED from pain in non-fully awake pediatric patients.
Main Methods:
- Review of current literature on pediatric emergence delirium and pain.
- Analysis of diagnostic challenges and risk factors for ED.
- Discussion of treatment strategies for ED and pain.
Main Results:
- Emergence delirium (ED) incidence is estimated between 10% and 20%.
- Risk factors for ED include young age, male gender, preoperative anxiety, and specific surgeries.
- Current assessment tools struggle to reliably distinguish ED from pain in awake children.
Conclusions:
- Accurate differentiation between ED and pain is crucial for appropriate treatment.
- Misdiagnosis can lead to undertreated pain or overuse of opioids for ED.
- A pragmatic approach is needed to guide clinical practice in managing post-anesthesia unsettled behaviors.
Abstract:
Unsettled behaviors characterize the early phase after general anaesthesia in the pediatric population in up to 80% of cases. Emergence delirium (ED) and acute pain are the two most relevant sources of this phenomenon. Research and clinical guidelines are difficult to implement due to the variability of the definition of unsettled behavior and measurement of the different components. The most probable incidence of ED is between 10% and 20%, and the potential risk factors could be summarized as young age, male gender, preoperative anxiety, baseline sleep-disordered breathing, volatile anaesthesia and ENT or ophthalmologic surgery. Self-reporting behavioral and observational scales are unable to reliably differentiate between ED and pain in a child who is not fully awake, making correct treatment choices difficult. This may lead to an undertreatment of pain in agitated children or to the overuse of opioids for self-limiting ED. This paper considers the current knowledge on the identification and treatment of ED and pain and provides a pragmatic approach for daily practice.
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