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Association between Serum Soluble Urokinase-Type Plasminogen Activator Receptor Level and Arterial Stiffness in

Wei-Chen Lin1, Tsung-Jui Wu2,3,4, Chih-Hsien Wang1,5

  • 1Division of Nephrology, Department of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, Taiwan.

Journal of Personalized Medicine
|March 29, 2023
PubMed

Insights

Soluble urokinase-type plasminogen activator receptor (suPAR) is linked to arterial stiffness in hemodialysis patients. Higher suPAR levels independently predict arterial stiffness, suggesting its potential as a biomarker for cardiovascular risk.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarkers

Background:

  • Cardiovascular diseases (CVDs) are a leading cause of mortality in hemodialysis (HD) patients.
  • Arterial stiffness is a significant CVD risk factor in this population.

Purpose of the Study:

  • To investigate the association between soluble urokinase-type plasminogen activator receptor (suPAR) and arterial stiffness in chronic HD patients.
  • To determine if suPAR can serve as a biomarker for arterial stiffness in HD patients.

Main Methods:

  • Cross-sectional study of 135 chronic HD patients.
  • Arterial stiffness assessed by carotid-femoral pulse-wave velocity (cfPWV >10 m/s).
  • Multivariable logistic and linear regression analyses were performed to identify independent predictors of arterial stiffness.

Main Results:

  • Fifty-five patients (40.7%) exhibited arterial stiffness.
  • Patients with arterial stiffness had higher prevalence of diabetes, hypertension, and elevated levels of glucose, C-reactive protein, and suPAR.
  • Serum suPAR was independently associated with arterial stiffness (OR: 2.05; 95% CI: 1.48-2.70, p < 0.001) and positively correlated with cfPWV (β = 0.475, p < 0.001).

Conclusions:

  • Serum suPAR is a significant independent predictor of arterial stiffness in patients undergoing chronic hemodialysis.
  • suPAR may serve as a valuable biomarker for detecting and managing arterial stiffness in HD patients, aiding in cardiovascular risk assessment.

Keywords:
arterial stiffnesscarotid–femoral pulse-wave velocityhemodialysissoluble urokinase-type plasminogen activator receptor

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