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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Aug 5, 2025

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Melanoma and Nevi Subtype Histopathological Characterization with Optical Coherence Tomography.

Cristina L Saratxaga1,2, Aintzane Asumendi3,4, Jesús Gardeazabal4,5

  • 1TECNALIA, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, C/Geldo. Edificio 700, 48160 Derio, Spain.

Life (Basel, Switzerland)
|March 29, 2023
PubMed
Summary

Optical coherence tomography (OCT) shows promise in differentiating melanoma subtypes. Preliminary analysis reveals distinct features between melanoma in-situ and invasive melanoma, aiding dermatologists in lesion assessment.

Keywords:
CADxHEOCThistopathologymelanomaoptical biopsyoptical propertiesskin cancertextural properties

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Area of Science:

  • Dermatology
  • Medical Imaging
  • Oncology

Background:

  • Melanoma incidence is rising, necessitating improved diagnostic tools.
  • Differentiating non-invasive (e.g., melanoma in-situ) from invasive melanoma is crucial for dermatologists.
  • Optical coherence tomography (OCT) is a studied non-invasive imaging technique with ongoing debate regarding its diagnostic utility for melanoma.

Purpose of the Study:

  • To comparatively analyze OCT images against histopathological features (hematoxylin-eosin staining).
  • To extract optical and textural properties from OCT images.
  • To identify subtle features for improved assessment of lesion invasiveness using OCT.

Main Methods:

  • Comparative analysis of OCT images and pathologist-identified features.
  • Extraction of optical and textural properties from OCT data.
  • Utilizing feature extraction to assess potential invasiveness of skin lesions.

Main Results:

  • Preliminary OCT features show discriminatory potential between melanoma in-situ and superficial spreading melanoma.
  • Distinct features identified between melanoma and nevus subtypes.
  • Promising baseline established for further OCT-based melanoma research.

Conclusions:

  • Directly diagnosing non-invasive versus invasive lesions with OCT is not yet feasible.
  • The study represents a significant step forward in utilizing OCT for melanoma diagnosis.
  • OCT shows potential for identifying subtle features relevant to melanoma invasiveness.