Related Experiment Video
Updated: Aug 5, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Contrasting Autoimmune Comorbidities in Microscopic Colitis and Inflammatory Bowel Diseases
Istvan Fedor1,2, Eva Zold2, Zsolt Barta3
1Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, Kassai Street 26, 4012 Debrecen, Hungary.
Inflammatory bowel diseases (IBD) with colonic involvement increase autoimmune disease risk. Ulcerative colitis patients may show autoimmunity markers without a definitive diagnosis.
Area of Science:
- Gastroenterology
- Immunology
- Internal Medicine
Background:
- Inflammatory bowel diseases (IBD) and microscopic colitis (MC) are distinct immune-mediated gastrointestinal disorders.
- Understanding their association with other autoimmune conditions is crucial for patient management.
Purpose of the Study:
- To compare autoimmune disease prevalence in patients with MC versus IBD.
- To investigate the impact of colonic involvement on autoimmune disease development.
Main Methods:
- Retrospective analysis of 611 patients (508 IBD, 103 MC) between 2008-2022.
- Documentation review for co-existing autoimmune diseases.
- Assessment of disease location (colonic vs. ileal) in IBD.
Main Results:
- Patients with ulcerative colitis and colonic-predominant Crohn's disease showed higher autoimmune disease rates.
- Gluten-related disorders were more frequent in Crohn's disease compared to ulcerative colitis and MC.
- Ten ulcerative colitis patients had non-differentiated collagenosis, indicating potential future autoimmune disease.
Conclusions:
- Colonic involvement in IBD may predispose patients to additional autoimmune disorders.
- Ulcerative colitis patients can exhibit autoimmunity markers (non-differentiated collagenosis) without meeting criteria for defined autoimmune diseases.
More Related Videos
08:24Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
06:57Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
Related Concept Videos
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents