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Updated: Aug 5, 2025

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
Published on: March 31, 2011
Greener Grass: The Modern History of Epithelial Stem Cell Innovation
Keshia Pitt1, Yoshiyuki Mochida1,2, Makoto Senoo1,2,3
1Graduate Program in Molecular and Translational Medicine, Boston University Chobanian & Avedisian School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.
Abstract:
The field of epithelial stem cell development has been irrevocably shaped by the work of American scientist Howard Green, whose breakthroughs in stem cell culture methods translated to therapeutic practice. In this review, we chronicle the milestones that propelled the field of regenerative medicine of the skin forward over the last fifty years. We detail the early discoveries made by Green and his collaborators, highlight clinical cases that made life-saving use of his findings, and discuss the accomplishments of other scientists who later innovated upon his discoveries.
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