Multilayer Methacrylate-Based Wound Dressing as a Therapeutic Tool for Targeted Pain Relief

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Nanotechnology

Background:

• Painful wounds require effective therapeutic solutions.
• Current treatments may lack targeted delivery or sustained release mechanisms.
• Diclofenac is a common non-steroidal anti-inflammatory drug for pain management.

Purpose of the Study:

• To develop an innovative, active wound dressing system for targeted pain relief.
• To incorporate diclofenac into a biocompatible matrix for sustained release.
• To utilize superparamagnetic nanoparticles for enhanced dressing properties.

Main Methods:

• Embedding diclofenac within a polyhydroxyethyl methacrylate and polyhydroxypropyl methacrylate matrix.
• Fabricating a multilayered dressing using layer-by-layer coating.
• Incorporating superparamagnetic iron platinum nanoparticles.
• Characterizing physicochemical, structural, and morphological properties.
• Assessing biocompatibility with human skin fibroblasts.

Main Results:

• The multilayered structure facilitated sustained drug release and precise application.
• Synergistic effects of diclofenac and nanoparticles controlled surface roughness and release kinetics.
• The developed wound dressings demonstrated biocompatibility with human skin fibroblasts.
• Controlled drug release was achieved through optimized formulation and structure.

Conclusions:

• The developed multilayered wound dressing system offers a promising therapeutic strategy for local pain relief.
• The system provides targeted delivery and sustained release of diclofenac.
• The incorporation of superparamagnetic nanoparticles enhances the dressing's performance.
• This innovation contributes to tailored therapeutic approaches for wound pain management.