Bone scan appearance of osteogenesis imperfecta in an adult

An adult patient with undiagnosed osteogenesis imperfecta presented with a history of multiple fractures. Radiographs could not definitively diagnose the underlying abnormality. The radionuclide bone image suggested the presence of a skeletal dysplasia, and prompted the histopathologic review of fracture fragments. The scan appearance of osteogenesis imperfecta in the adult and possible underlying mechanisms for the radiopharmaceutical distribution are discussed.