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Screening for bacteriuria with the LN strip test.

G V Doern, M A Saubolle, D L Sewell

    Diagnostic Microbiology and Infectious Disease
    |April 1, 1986
    PubMed
    Summary
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    The LN strip test offers rapid screening for bacteriuria by detecting leukocyte esterase and nitrite in urine. This test showed 88.8% sensitivity and 71.3% specificity when compared to urine culture.

    Area of Science:

    • Clinical Chemistry
    • Microbiology
    • Urology

    Background:

    • Bacteriuria, the presence of bacteria in urine, is a common clinical finding.
    • Rapid and accurate screening methods for bacteriuria are essential for timely diagnosis and treatment.
    • The LN strip test, which detects urinary leukocyte esterase and nitrite, has been introduced for rapid urine specimen screening.

    Purpose of the Study:

    • To evaluate the diagnostic performance of the LN strip test for detecting bacteriuria.
    • To compare the LN strip test results with conventional quantitative urine culture techniques.

    Main Methods:

    • A total of 2,481 unselected urine specimens were analyzed.
    • Specimens were tested using the LN strip test (detecting leukocyte esterase and nitrite).

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  • Results were compared against quantitative urine culture (reference standard).

    • Main Results:

    • The combined leukocyte esterase and nitrite tests demonstrated 88.8% sensitivity and 71.3% specificity for bacteriuria (≥10(5) CFU/ml).
    • Sensitivity decreased at lower bacterial counts (≥10(4) CFU/ml).
    • Specificity increased at lower bacterial counts (≥10(4) CFU/ml).

    Conclusions:

    • The LN strip test provides a rapid screening method for bacteriuria.
    • The test exhibits good sensitivity but moderate specificity, particularly at lower bacterial concentrations.
    • Further refinement or combination with other diagnostic methods may be beneficial for clinical decision-making.