Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

5.8K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
5.8K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Signal Transduction: Overview01:26

Signal Transduction: Overview

8.6K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
8.6K
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

3.4K
A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
3.4K
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

4.5K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.5K
Cell-surface Signaling01:21

Cell-surface Signaling

52.0K
Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
52.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipid Composition Drives Mutant Huntingtin Dimerization and Membrane Association: Insights from Computational Simulations.

Molecules (Basel, Switzerland)·2026
Same author

Sustained Palmitoylethanolamide Infusion Restores Incentive Motivation and Synaptic Plasticity in the Tg2576 Mouse Model of Alzheimer's Disease.

Cells·2026
Same author

Unraveling Endocannabinoid Signaling Pathways in Cisplatin-Induced Ototoxicity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

FAAH Modulators from Natural Sources: A Collection of New Potential Drugs.

Cells·2025
Same author

FAAH Inhibition Counteracts Neuroinflammation via Autophagy Recovery in AD Models.

International journal of molecular sciences·2024
Same author

Alterations of endocannabinoid signaling and microglia reactivity in the retinas of AD-like mice precede the onset of hippocampal β-amyloid plaques.

Journal of neurochemistry·2024

Related Experiment Video

Updated: Aug 5, 2025

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

2.4K

Deciphering Complex Interactions in Bioactive Lipid Signaling.

Mauro Maccarrone1,2

  • 1Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

Molecules (Basel, Switzerland)
|March 29, 2023
PubMed
Summary

Bioactive lipids, including eicosanoids and endocannabinoids, act as crucial cell messengers. Their interactions and signaling pathways are vital for regulating health and disease processes.

Keywords:
biased signalingeicosanoidendocannabinoidmetabolismsignal transductionspecialized pro-resolving mediatorsphingosine-1-phosphatesteroid

More Related Videos

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors GPCRs
09:45

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors GPCRs

Published on: February 5, 2022

3.6K
Lipid Exchange Assay in Living Cells
08:59

Lipid Exchange Assay in Living Cells

Published on: March 21, 2025

592

Related Experiment Videos

Last Updated: Aug 5, 2025

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

2.4K
Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors GPCRs
09:45

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors GPCRs

Published on: February 5, 2022

3.6K
Lipid Exchange Assay in Living Cells
08:59

Lipid Exchange Assay in Living Cells

Published on: March 21, 2025

592

Area of Science:

  • Biochemistry
  • Cell Biology
  • Physiology

Background:

  • Lipids are traditionally recognized for their roles as metabolic fuel and structural membrane components.
  • Recent discoveries highlight diverse lipid families functioning as critical intercellular and intracellular messengers.
  • These lipid signals mediate biological activities through specific receptors, influencing numerous pathophysiological processes.

Purpose of the Study:

  • To present endogenous bioactive lipids derived from arachidonic acid (AA) and other poly-unsaturated fatty acids.
  • To elucidate the significance of mutual interactions among these lipid signals in health and disease.
  • To discuss the metabolism, signal transduction, and receptor interactions of various bioactive lipid classes.

Main Methods:

  • Description of metabolism and signal transduction pathways for classical eicosanoids, endocannabinoids, and specialized pro-resolving mediators.
  • Analysis of intersections and commonalities in metabolic enzymes and binding receptors.
  • Exploration of interactions between AA-derived signals and other bioactive lipids like sphingosine-1-phosphate and steroid hormones.

Main Results:

  • Identification of distinct signaling roles for various lipid families beyond traditional functions.
  • Elucidation of shared metabolic enzymes and receptor targets among different bioactive lipid classes.
  • Characterization of cross-talk between AA-derived mediators and other lipid signaling molecules.

Conclusions:

  • Bioactive lipids are key regulators of cellular communication and physiological functions.
  • Understanding the complex interplay of lipid signaling pathways is crucial for comprehending health and disease.
  • Targeting these pathways offers potential therapeutic strategies for various pathophysiological conditions.