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Capsaicin and Zinc Signalling Pathways as Promising Targets for Managing Insulin Resistance and Type 2 Diabetes
Parisa Vahidi Ferdowsi1,2, Kiran D K Ahuja1, Jeffrey M Beckett1
1School of Health Sciences, College of Health and Medicine, University of Tasmania, Newnham Drive, Launceston, TAS 7248, Australia.
Molecules (Basel, Switzerland)
|March 29, 2023
Summary
Capsaicin and zinc, bioactive food components, show potential in improving glucose metabolism for type 2 diabetes (T2DM). They activate distinct cellular pathways, offering novel therapeutic targets for T2DM management.
Area of Science:
- Biochemistry
- Metabolic Disorders
- Nutritional Science
Background:
- Type 2 diabetes (T2DM) presents a significant global health challenge.
- Bioactive food components offer promising avenues for managing abnormal glucose metabolism.
- Capsaicin and zinc are identified as key food components with potential glucose-lowering effects.
Purpose of the Study:
- To review the molecular signaling pathways activated by capsaicin and zinc.
- To explore the potential of these pathways as novel therapeutic targets for T2DM.
- To summarize the current understanding of capsaicin and zinc's role in glucose metabolism.
Main Methods:
- Literature review of scientific studies on capsaicin, zinc, and glucose metabolism.
- Analysis of signaling events, including AMPK and AKT pathways.
- Identification of common pathways like calcium signal transduction.
Main Results:
- Capsaicin activates the AMPK pathway, enhancing glucose uptake.
- Zinc stimulates glucose uptake via the AKT pathway.
- Calcium signal transduction emerges as a potential common pathway for both compounds.
Conclusions:
- Capsaicin and zinc modulate glucose metabolism through distinct yet potentially interconnected signaling pathways.
- Investigating these molecular mechanisms could reveal new therapeutic strategies for T2DM.
- Dietary bioactive compounds like capsaicin and zinc hold promise for T2DM management.
Keywords:
CAMKKCREBTORCcalcium signallingcapsaicinglucose metabolisminsulin resistancetype 2 diabeteszincMore Related Videos
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