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Magnesium Improves Cardiac Function in Experimental Uremia by Altering Cardiac Elastin Protein Content
Xoana Barros1,2, Xenia Friesen1, Vincent Mathias Brandenburg3
1Division of Nephrology and Rheumatology, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Nutrients
|March 29, 2023
Summary
Magnesium supplementation improved cardiac function and aortic wall integrity in rats with chronic kidney disease (CKD). This study highlights magnesium
Area of Science:
- Nephrology
- Cardiology
- Biochemistry
Background:
- Cardiovascular complications are the leading cause of death in chronic kidney disease (CKD) patients.
- Magnesium deficiency is prevalent in CKD and crucial for cardiac function.
Purpose of the Study:
- To investigate the effects of oral magnesium carbonate supplementation on cardiac function in a rat model of CKD.
Main Methods:
- CKD was induced in Wistar rats using an adenine diet.
- Echocardiography was used to assess cardiac function.
- Cardiac histology and real-time PCR analyzed elastin and collagen III expression.
- Aortic calcium content was measured.
Main Results:
- Magnesium supplementation restored impaired left ventricular cardiac function in CKD rats.
- Increased elastin protein and collagen III expression were observed in magnesium-supplemented CKD rats.
- Magnesium supplementation numerically reduced aortic calcium content.
Conclusions:
- Oral magnesium carbonate improves cardiovascular function in a rat model of CKD.
- Magnesium supplementation enhances aortic wall integrity by modulating structural protein expression.
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