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Enhanced Skin Penetration of Cannabidiol Using Organosilane Particles as Transdermal Delivery Vehicles
Zahra Khabir1, Connie Partalis2, Jimit Vijay Panchal1,2
1Australian Research Council, Industrial Transformation Training Centre for Facilitated, Advancement of Australia's Bioactives (FAAB), Macquarie University, Sydney, NSW 2109, Australia.
Pharmaceutics
|March 29, 2023
Summary
This study developed organosilica particles to encapsulate cannabidiol (CBD), improving its transdermal delivery through polyvinyl alcohol films. This novel method enhances CBD skin penetration, offering a promising alternative to oral administration for various therapeutic applications.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Biotechnology
Background:
- Cannabidiol (CBD) shows therapeutic potential but suffers from low oral bioavailability.
- Alternative drug delivery systems are needed to enhance CBD efficacy and patient outcomes.
- Encapsulation within novel delivery vehicles can improve CBD's physicochemical properties and administration routes.
Purpose of the Study:
- To develop and evaluate organosilica particles as drug delivery vehicles for cannabidiol (CBD).
- To assess the stability and release kinetics of CBD encapsulated in organosilica particles within polyvinyl alcohol (PVA) films.
- To investigate the transdermal penetration of CBD from the developed PVA formulation using an ex vivo skin model.
Main Methods:
- Encapsulation of CBD within organosilica particles, followed by incorporation into PVA films.
- Long-term stability testing of encapsulated CBD under various temperature and humidity conditions.
- In vitro release studies using simulated physiological fluids and characterization via FT-IR and HPLC.
- Ex vivo transdermal penetration studies using a human skin model.
Main Results:
- Encapsulated CBD demonstrated stability within PVA films for up to 14 weeks.
- CBD release followed first-order kinetics, indicating diffusion-controlled release from the silica matrix.
- The organosilica particles did not penetrate the stratum corneum, but CBD penetration into the lower epidermis was enhanced (0.41% vs. 0.27% for pure CBD).
- Enhanced penetration is attributed to improved solubility upon release and potential effects of the PVA matrix.
Conclusions:
- Organosilica particles effectively encapsulate CBD, enhancing its transdermal delivery via PVA films.
- This novel delivery system overcomes limitations of oral CBD administration, improving therapeutic potential.
- The developed membrane technology offers a promising route for non-oral and non-pulmonary delivery of CBD and other cannabinoids.
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