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Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics
Gloria Mora-Castaño1, Mónica Millán-Jiménez1, Isidoro Caraballo1
1Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Universidad de Sevilla, 41012 Seville, Spain.
Pharmaceutics
|March 29, 2023
Summary
Three-dimensional printing (3DP) creates personalized gastroretentive floating tablets for controlled drug release. This technology enhances therapeutic customization by ensuring robust release kinetics even with varying drug doses.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Additive Manufacturing
Background:
- Three-dimensional printing (3DP) offers advancements in designing novel drug delivery systems.
- Gastroretentive floating tablets provide improved temporal and spatial control over drug release.
- Customization of drug delivery systems is crucial for individual therapeutic needs.
Purpose of the Study:
- To prepare 3D printed gastroretentive floating tablets for controlled drug release.
- To investigate the use of metformin as a model drug and hydroxypropylmethyl cellulose as a carrier.
- To ensure robust release kinetics despite variations in drug dosage for personalized medicine.
Main Methods:
- Fused Deposition Modelling (FDM) 3DP was employed to fabricate floating tablets.
- Filaments with drug loads ranging from 10-50% w/w were utilized.
- The impact of variables like internal mesh size on drug release was analyzed.
Main Results:
- Successfully produced 3D printed gastroretentive floating tablets with sustained drug release exceeding 8 hours.
- Demonstrated successful buoyancy due to effective sealing layers.
- Identified that internal mesh size variation, affecting drug load, impacts release kinetics robustness.
Conclusions:
- 3D printing enables the creation of advanced gastroretentive floating tablets for controlled drug delivery.
- The study highlights the potential for personalized medicine through tunable drug release profiles.
- This approach represents a significant advancement in pharmaceutical 3DP applications.
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