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Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy
Yedi Herdiana1, Nasrul Wathoni1, Dolih Gozali1
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia.
Abstract:
Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity of breast cancer is a major challenge which is coupled with patient-to-patient variations and heterogeneity between cells within the tumor. Revolutionary drug delivery is expected to provide a solution to that challenge. Chitosan nanoparticles (CSNPs) have prospects as a revolutionary delivery system capable of enhancing anticancer drug activity and reducing negative impacts on normal cells. The use of smart drug delivery systems (SDDs) as delivering materials to improve the bioactivity of NPs and to understand the intricacies of breast cancer has garnered significant interest. There are many reviews about CSNPs that present various points of view, but they have not yet described a series in cancer therapy from cell uptake to cell death. With this description, we will provide a more complete picture for designing preparations for SDDs. This review describes CSNPs as SDDSs, enhancing cancer therapy targeting and stimulus response using their anticancer mechanism. Multimodal chitosan SDDs as targeting and stimulus response medication delivery will improve therapeutic results.
Insights
Chitosan nanoparticles (CSNPs) offer a promising approach to enhance breast cancer therapy. These smart drug delivery systems (SDDs) improve drug efficacy and reduce side effects by targeting cancer cells effectively.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Cancer remains a leading global health threat, necessitating novel therapeutic strategies.
- Breast cancer presents significant challenges due to its complexity and cellular heterogeneity.
- Conventional treatments often have limitations, driving the need for advanced drug delivery systems.
Purpose of the Study:
- To review chitosan nanoparticles (CSNPs) as smart drug delivery systems (SDDs) for cancer therapy.
- To elucidate the mechanism of CSNPs from cellular uptake to cell death in cancer treatment.
- To highlight the potential of multimodal chitosan SDDs in enhancing targeted cancer therapy.
Main Methods:
- Review of existing literature on chitosan nanoparticles in cancer therapy.
- Analysis of CSNP mechanisms in drug delivery and anticancer activity.
- Exploration of stimulus-responsive and targeting strategies for CSNPs.
Main Results:
- CSNPs demonstrate potential as effective carriers for anticancer drugs.
- SDDs based on CSNPs can enhance drug bioavailability and reduce toxicity to normal cells.
- Multimodal chitosan SDDs offer improved targeting and stimulus-responsive drug release.
Conclusions:
- Chitosan nanoparticles represent a promising platform for developing advanced smart drug delivery systems for breast cancer.
- Understanding the complete therapeutic pathway of CSNPs is crucial for designing effective cancer treatments.
- Multimodal chitosan SDDs hold significant potential to improve therapeutic outcomes in cancer therapy.
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