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Related Experiment Video

Updated: Aug 5, 2025

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
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Size-Controllable Nanosystem with Double Responsive for Deep Photodynamic Therapy.

Shuang-Shuang Wan1, Jun Tao1, Qian Wu1

  • 1State Key Laboratory of Organic Electronics and Information Displays, Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.

Pharmaceutics
|March 29, 2023
PubMed
Summary

This study introduces a novel nanosystem for deep photodynamic therapy (PDT) in cancer treatment. The system enhances light penetration and tumor specificity, improving treatment efficacy and biosafety.

Keywords:
cancermetal-organic frameworkphotodynamic therapyself-assemblyupconverting nanoparticle

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Photodynamic therapy (PDT) shows promise for cancer treatment but faces challenges with light penetration and specificity.
  • Developing advanced nanocarriers is crucial for overcoming these limitations in clinical applications.

Purpose of the Study:

  • To design and construct a size-controllable, inside-out responsive nanosystem (UPH) for enhanced deep PDT.
  • To improve tumor targeting, light penetration, and biosafety of PDT agents.

Main Methods:

  • Synthesized core-shell nanoparticles (UCNP@nPCN) using layer-by-layer assembly for optimal quantum yield.
  • Coated nanoparticles with hyaluronic acid (HA) to create UPH nanoparticles for tumor-specific uptake via CD44 receptors.
  • Utilized 980 nm near-infrared (NIR) light activation and fluorescence resonance energy transfer (FRET) for reactive oxygen species generation.

Main Results:

  • UPH nanoparticles demonstrated preferential accumulation at tumor sites and specific endocytosis.
  • Activated UPH nanoparticles efficiently generated reactive oxygen species, leading to significant tumor growth inhibition in vitro and in vivo.
  • The nanosystem exhibited enhanced biosafety with negligible side effects.

Conclusions:

  • The developed UPH nanosystem enables effective deep PDT for solid tumors.
  • This dual-responsive nanoplatform offers a promising strategy for clinical translation in cancer therapy.