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Drug Delivery Strategies for Avobenzone: A Case Study of Photostabilization
Amol D Gholap1,2, Sadikali F Sayyad2, Navnath T Hatvate3
1Department of Pharmaceutics, St. John Institute of Pharmacy and Research, Palghar 401404, Maharashtra, India.
Pharmaceutics
|March 29, 2023
Summary
Photodegradation limits avobenzone
Area of Science:
- Drug technology and formulation science
- Photochemistry and photophysics
- Dermatology and cosmetic science
Background:
- UV radiation causes DNA damage and skin cancer.
- Sunscreens protect skin, but UV filters like avobenzone can degrade.
- Avobenzone's keto-enol tautomerism leads to photodegradation, limiting its efficacy.
Purpose of the Study:
- To review drug delivery strategies for photostabilizing avobenzone.
- To identify effective and safe sunscreen agents.
- To inform industrial strategies for overcoming avobenzone's photounstability.
Main Methods:
- Literature review of photoprotection strategies.
- Analysis of drug delivery systems for UV filters.
- Evaluation of encapsulation, antioxidants, photostabilizers, and quenchers.
Main Results:
- Multiple strategies exist to improve avobenzone's photostability.
- Combinations of approaches show promise for enhanced photoprotection.
- Drug delivery systems offer potential for large-scale industrial application.
Conclusions:
- Photostabilization of avobenzone is crucial for effective sunscreens.
- Drug delivery strategies are key to overcoming avobenzone's limitations.
- Further research can lead to improved, photostable sunscreen formulations.
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