A High-Linearity Glucose Sensor Based on Silver-Doped Con A Hydrogel and Laser Direct Writing

Area of Science:

• Biomedical Engineering
• Materials Science
• Analytical Chemistry

Background:

• Continuous glucose monitoring (CGM) is crucial for diabetic patient blood glucose control.
• Developing flexible, highly linear glucose sensors for wide detection ranges remains a significant challenge.
• Enzyme-free glucose sensors offer an alternative to traditional methods, but performance needs improvement.

Purpose of the Study:

• To develop a novel flexible, enzyme-free glucose sensor with enhanced performance for continuous glucose monitoring.
• To address the limitations of existing glucose sensors in terms of linearity, sensitivity, and flexibility.
• To investigate the potential of silver-doped Concanavalin A hydrogels for glucose detection.

Main Methods:

• Fabrication of a flexible enzyme-free glucose sensor using laser direct-writing graphene electrodes.
• Incorporation of silver particles and Concanavalin A-based glucose-responsive hydrogels.
• Characterization of sensor performance, including sensitivity, linearity, and repeatability across a wide glucose concentration range (0-30 mM).

Main Results:

• The proposed sensor demonstrated repeatable and reversible glucose level measurements within the 0-30 mM range.
• Achieved a high sensitivity of 150.12 Ω/mM and excellent linearity with R² = 0.97.
• The sensor exhibited high performance and a straightforward manufacturing process.

Conclusions:

• The silver-doped Concanavalin A-based hydrogel sensor represents a significant advancement in enzyme-free glucose sensing.
• The sensor's high performance and simple fabrication make it a promising candidate for next-generation continuous glucose monitoring devices.
• This technology has strong potential for improving blood glucose management in diabetic patients.