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Coronavirus Disease 2019 Convalescent Plasma Utilization in the United States: Data From the National Inpatient

Evan M Bloch1, Ruchika Goel1,2, Xianming Zhu1

  • 1Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|March 29, 2023
PubMed

Insights

COVID-19 convalescent plasma (CCP) was given to 18% of hospitalized patients. Its use correlated with older age and severe illness, with racial, geographic, and insurance-based disparities noted.

Area of Science:

  • Infectious Diseases
  • Hematology
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19) is a significant global health concern.
  • COVID-19 convalescent plasma (CCP) emerged as a potential therapeutic option.
  • Understanding the real-world utilization patterns of CCP is crucial for clinical practice and health policy.

Purpose of the Study:

  • To characterize the utilization of CCP in COVID-19-associated hospitalizations.
  • To identify factors associated with CCP administration.
  • To examine disparities in CCP receipt among different patient populations.

Main Methods:

  • Retrospective analysis of the National Inpatient Sample database.
  • Inclusion of hospitalizations between October and December 2020.
  • Statistical analysis to determine associations and disparities in CCP use.

Main Results:

  • CCP was administered in 18.0% of COVID-19 hospitalizations.
  • CCP administration was strongly associated with older patient age and increased disease severity.
  • Significant disparities in CCP receipt were observed based on race and ethnicity, geographic location, and insurance status.

Conclusions:

  • CCP was utilized in a notable proportion of COVID-19 hospitalizations during the study period.
  • Patient demographics and disease severity were key factors influencing CCP administration.
  • Equitable access to CCP was not consistently observed, highlighting potential systemic inequities.

Keywords:
COVID-19COVID-19 serotherapySARS-CoV-2blood donorsblood transfusion

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