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Intracranial hypertension after cerebral venous thrombosis-Risk factors and outcomes

Huimin Wei1,2, Huimin Jiang2, Yifan Zhou2

  • 1Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.

CNS Neuroscience & Therapeutics
|March 29, 2023
PubMed

Insights

Intracranial hypertension is common in cerebral venous thrombosis (CVT). Patients with CVT and intracranial hypertension face higher risks of visual impairment, highlighting the need for targeted management strategies.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Stroke Research

Background:

  • Cerebral venous thrombosis (CVT) is a rare cerebrovascular disease, often affecting younger adults.
  • Intracranial hypertension is a frequent complication of acute CVT, resulting from venous occlusion.
  • Understanding CVT's risk factors and impact on patient outcomes is crucial for effective management.

Purpose of the Study:

  • To identify risk factors for intracranial hypertension in patients with CVT.
  • To investigate the association between intracranial hypertension at diagnosis and patient outcomes.
  • To explore predictors of residual visual impairment following CVT.

Main Methods:

  • Retrospective cohort analysis of 293 acute/subacute CVT survivors (2018-2021).
  • Logistic regression analysis to determine risk factors for intracranial hypertension and clinical outcomes.
  • 6-month follow-up to assess functional status and visual impairment.

Main Results:

  • 83.6% of CVT survivors had intracranial hypertension at diagnosis.
  • Hereditary thrombophilia and specific sinus thrombosis locations (superior sagittal and right lateral sinuses) were linked to intracranial hypertension.
  • Patients with intracranial hypertension had favorable functional outcomes but a higher incidence of residual visual impairment.

Conclusions:

  • Intracranial hypertension is the most common symptom of acute CVT.
  • CVT patients with intracranial hypertension are at increased risk for residual visual impairment.
  • Papilledema, visual disturbances, specific thrombosis locations, and CVT recurrence predict visual impairment.
Abstract

Keywords:
cerebral venous thrombosiscerebrovascular diseaseintracranial hypertensionraised intracranial pressureresidual visual impairment

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