[Correlation between chronic sinusitis subtypes and basophil levels in peripheral blood].

Area of Science:

• Immunology
• Otolaryngology
• Medical Diagnostics

Context:

• Chronic sinusitis (CRS) is a heterogeneous inflammatory condition of the upper airway.
• Subtyping CRS, particularly distinguishing eosinophilic CRS (eCRS), is crucial for targeted treatment.
• Peripheral blood inflammatory cell profiles are increasingly investigated for their role in systemic inflammation and disease correlation.

Purpose:

• To investigate the clinical correlation between peripheral blood basophil levels and different subtypes of chronic sinusitis (CRS).
• To compare basophil counts and related ratios (basophils-to-lymphocytes ratio [BLR], basophils-to-monocytes ratio [BMR]) across healthy controls, eCRS, and non-eCRS groups.
• To assess the association of these basophil-related markers with the Lund-Mackay score in CRS patients.

Summary:

• Peripheral blood basophil counts, BLR, and BMR were significantly elevated in the eCRS group compared to healthy controls and the non-eCRS group.
• Basophil counts, BLR, and BMR showed a positive correlation with the Lund-Mackay score in CRS patients.
• Peripheral blood basophils also demonstrated positive correlations with eosinophils, lymphocytes, and monocytes in CRS patients.

Impact:

• Elevated peripheral blood basophil levels and associated ratios in eCRS suggest their potential as diagnostic biomarkers.
• The correlation with disease severity (Lund-Mackay score) highlights the clinical relevance of these findings.
• These results indicate that peripheral blood basophils could represent novel therapeutic targets for managing eosinophilic chronic sinusitis.