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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

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Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
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Related Experiment Video

Updated: Aug 5, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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[Corticosteroids and glaucoma].

Hana Abouzeid1, Lara Sintzoff2

  • 1Service d'ophtalmologie, Département des neurosciences cliniques, Hôpitaux universitaires de Genève, 1211 Genève 14.

Revue Medicale Suisse
|March 29, 2023
PubMed
Summary

Corticosteroid use can increase intraocular pressure (IOP), a risk factor for glaucoma. Monitoring IOP and patient education are key to preventing and managing this steroid-induced ocular hypertension.

Area of Science:

  • Ophthalmology
  • Pharmacology

Context:

  • Corticosteroids are frequently used for ocular and systemic conditions.
  • Elevated intraocular pressure (IOP) is a significant risk factor for glaucoma development and progression.
  • Individual variability in IOP response to corticosteroids, termed steroid responsiveness, is a recognized phenomenon.

Purpose:

  • To review the impact of corticosteroid use on intraocular pressure.
  • To identify risk factors associated with steroid-induced ocular hypertension.
  • To outline strategies for the prevention and management of corticosteroid-induced glaucoma.

Summary:

  • Corticosteroid administration is a primary risk factor for inducing or worsening glaucoma by increasing intraocular pressure (IOP).
  • Steroid responsiveness, the individual variation in IOP elevation due to corticosteroids, is influenced by factors such as a personal or family history of primary open-angle glaucoma.

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  • The degree of IOP elevation is also dependent on the specific corticosteroid preparation, administration route, dosage, and treatment duration.

    • Impact:

    • Highlights the critical need for vigilance regarding corticosteroid-induced IOP elevation in clinical practice.
    • Emphasizes proactive patient and practitioner education as a cornerstone of prevention.
    • Underscores the importance of regular IOP monitoring during and after corticosteroid therapy to mitigate glaucoma risk.