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Cefoperazone-induced coagulopathy.

H R Freedy, A B Cetnarowski, R M Lumish

    Drug Intelligence & Clinical Pharmacy
    |April 1, 1986
    PubMed
    Summary
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    Antibiotic therapy, specifically cefoperazone, can cause hypoprothrombinemia, leading to prolonged prothrombin time and bleeding. Monitoring prothrombin time during cefoperazone treatment is crucial to prevent these adverse effects.

    Area of Science:

    • Pharmacology
    • Hematology
    • Internal Medicine

    Background:

    • Antibiotic-associated coagulopathies are an emerging concern.
    • Hypoprothrombinemia and bleeding are potential side effects of certain antibiotic therapies.

    Observation:

    • Three cases of bleeding linked to prolonged prothrombin time during cefoperazone therapy are presented.
    • This highlights a specific risk associated with cefoperazone use.

    Findings:

    • Cefoperazone therapy can induce hypoprothrombinemia, characterized by an extended prothrombin time.
    • The observed bleeding events were directly correlated with this laboratory finding.

    Implications:

    • Clinicians should be vigilant for bleeding risks in patients receiving cefoperazone.

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  • Regular monitoring of prothrombin time is recommended during cefoperazone treatment to mitigate bleeding complications.