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Published on: October 12, 2017
Correlation of apolipoprotein A-I with T cell subsets and interferon-ү in coronary artery disease
Xinlin Xiong1,2, Zonggang Duan1, Haiyan Zhou1
1Department of cardiology, The Affiliated Hospital of Guizhou Medical University, Guiyang city, Guizhou Province, People's Republic of China.
Background:
The association of Apolipoprotein A-I (APOAI) with T cell subsets and interferon-ү (IFN-γ) in patients with coronary artery disease (CAD) has been not reported. Thus, this study aimed to investigate the association of APOAI with T cell subsets and IFN-γ in CAD.
Methods:
This study included a total of 107 patients with CAD including acute coronary syndrome and chronic coronary syndrome. T cell subsets, and CD3-CD56+ natural killer cells were quantified by flow cytometric analysis. The serum concentrations of IFN-ү were measured by enzyme-linked immunosorbent assay. Lipid profiles, C-reactive protein (CRP), and fibrinogen were measured in the clinical laboratory. Clinical data was obtained duration hospitalization.
Results:
The CD4+ T cells were higher in patients of the low-APOAI group (
Conclusion:
The present study demonstrated the correlation of APOAI with T cell subsets and IFN-γ in CAD. These results provided novel information for the regulatory action between APOAI and T cell subsets and inflammatory immunity in CAD.
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