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Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Updated: Aug 5, 2025

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

Oxygen-Generating Biomaterials for Translational Bone Regenerative Engineering.

Fatemeh S Hosseini^1,2,3,4, Amir Abbas Abedini^1,2,5, Feiyang Chen¹

¹Connecticut Convergence Institute for Translation in Regenerative Engineering, UConn Health, Farmington, Connecticut 06030, United States.

ACS Applied Materials & Interfaces

|March 29, 2023

Summary

This summary is machine-generated.

Oxygen-generating biomaterials can enhance bone regeneration by overcoming hypoxia in critical-size defects. This review explores advanced oxygen delivery methods for improved stem cell survival and tissue ingrowth in bone repair.

Keywords:

biomaterials bone regeneration oxygen peroxide tissue engineering

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

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Last Updated: Aug 5, 2025

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

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Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Area of Science:

Biomaterials Science
Regenerative Engineering
Tissue Engineering

Background:

Critical-size bone defects pose significant challenges in regenerative engineering.
Current matrices often fail to supply adequate oxygen to stem cells, leading to central necrosis.
Limited vascularization in large defects exacerbates nutrient and oxygen deficiency.

Purpose of the Study:

To review recent advancements in oxygen-generating biomaterials for bone regenerative engineering.
To discuss oxygen's role in bone regeneration and various oxygen delivery strategies.
To explore emerging oxygen delivery methods for translational applications.

Main Methods:

Review of literature on oxygen-generating biomaterials for bone regeneration.
Discussion of oxygen release and delivery mechanisms.
Analysis of fabrication methods for oxygen-releasing matrices.

Main Results:

Oxygen-generating materials can overcome central hypoxia in large bone defect matrices.
These materials promote tissue ingrowth and enhance the quality of bone regeneration.
Various oxygen-releasing and delivery strategies are being developed for clinical translation.

Conclusions:

Oxygen-generating biomaterials offer a promising solution for challenging bone defects.
Understanding oxygen's biological role is crucial for designing effective regenerative strategies.
Emerging oxygen delivery technologies hold potential for improving patient outcomes in bone repair.