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In Vitro Fertilization01:24

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
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Cleavage and Blastulation01:33

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After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
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Human Blastocyst Biopsy and Vitrification
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Human Uterine Lavage: First Live Births from In Vivo Conceived Genetically Screened Blastocysts.

Sam Najmabadi1, José L Rivas2, Marlane J Angle3

  • 1Center for Reproductive Health and Gynecology, 99 N. La Cienega Blvd., Suite 109, Beverly Hills, CA, 90211, USA.

Advances in Therapy
|March 29, 2023
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Summary

Live births were achieved from genetically screened human embryos obtained via uterine lavage, a novel, non-surgical method. This breakthrough validates uterine lavage for accessing in vivo conceived embryos for fertility treatments and genetic screening.

Keywords:
BlastocystEuploidHumanUterine lavage

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Area of Science:

  • Reproductive Medicine
  • Embryology
  • Minimally Invasive Procedures

Background:

  • Uterine lavage offers a non-surgical method for retrieving in vivo conceived embryos.
  • Existing methods for embryo retrieval are often invasive, such as surgical oocyte aspiration.
  • Automated devices have been developed to enhance the uterine lavage procedure.

Purpose of the Study:

  • To report the first live births from genetically screened human euploid blastocysts obtained through uterine lavage.
  • To validate the efficacy of uterine lavage for obtaining in vivo conceived embryos for transfer.
  • To assess the potential of uterine lavage for preimplantation genetic testing.

Main Methods:

  • An observational case series involving nine embryo transfer procedures.
  • In vivo conceived blastocysts were recovered via uterine lavage 5 days post-intrauterine insemination.
  • One to two blastocysts were transferred to eight infertile women.

Main Results:

  • A total of 14 blastocysts were transferred in eight women, resulting in a 36% implantation rate (5/14).
  • The live birth rate was 44% (4/9), with five infants born, including one set of twins.
  • The study achieved the first reported live births from genetically screened euploid blastocysts obtained by uterine lavage.

Conclusions:

  • Nonsurgical uterine lavage successfully facilitated live births from in vivo conceived and genetically screened blastocysts.
  • Uterine lavage provides a simplified, non-surgical approach to accessing naturally conceived embryos.
  • This method may be valuable for preimplantation genetic testing in both fertile and infertile populations.