Related Experiment Video
Updated: Aug 5, 2025
07:12
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
7.8K
Central Pain Sensitization in Patients with Chronic Plaque Psoriasis
Francesco Bellinato1, Paolo Gisondi2, Angelo Fassio2
1Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy. francesco.bellinato@univr.it.
Dermatology and Therapy
|March 29, 2023
Summary
Central sensitization (CS) is linked to psoriasis, especially in patients with psoriatic arthritis (PsA). This condition, characterized by heightened pain responses, impacts quality of life and mental health in psoriasis patients.
Area of Science:
- Dermatology
- Pain Medicine
- Rheumatology
Background:
- Central sensitization (CS) involves disproportionate pain responses, often seen in chronic pain and inflammatory conditions like psoriatic arthritis (PsA).
- CS has not been previously studied in patients with psoriasis.
Purpose of the Study:
- To investigate the presence and characteristics of central sensitization (CS) in patients diagnosed with chronic plaque psoriasis.
Main Methods:
- A cross-sectional observational study was conducted on 194 adult patients with moderate-to-severe psoriasis.
- Data collected included demographics, disease severity (PASI, DAPSA), comorbidities, and validated questionnaires (CSI, DLQI, GAD-7, PHQ-9).
Main Results:
- 10% of patients met the threshold for CS (CSI score ≥40).
- CS was more prevalent in patients with psoriasis and PsA (17%) compared to psoriasis alone (7%).
- Higher CSI scores correlated with increased disease severity (PASI), psoriatic arthritis (PsA), anxiety (GAD-7), depression (PHQ-9), and reduced quality of life (DLQI).
Conclusions:
- Central sensitization (CS) is associated with psoriasis, particularly in individuals with high disease severity, co-occurring PsA, anxiety, depression, and significant quality of life impairment.
Related Concept Videos
01:25Analgesia and Pain Management
694
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
694
01:44Nociception
28.2K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
28.2K
01:20Pain
532
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
532
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
21
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
21