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The Rome Foundation Global Epidemiology Study (RFGES) addressed limitations in previous research by surveying 22 disorders of gut-brain interactions (DGBI) in 33 countries. This comprehensive study provides reliable prevalence estimates and insights into DGBI burden.

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Area of Science:

  • Neurogastroenterology
  • Epidemiology
  • Gastroenterology

Background:

  • Previous epidemiological research on gut-brain interactions was hindered by methodological issues.
  • Limited study populations, diagnostic criteria, and geographic scope affected the reliability of prevalence estimates.
  • The Rome Foundation Global Epidemiology Study (RFGES) was initiated to overcome these limitations.

Purpose of the Study:

  • To conduct a comprehensive, multinational epidemiological study on 22 disorders of gut-brain interactions (DGBI) using rigorous methodology.
  • To determine the prevalence and understand the burden of DGBI globally and regionally.
  • To enhance understanding of irritable bowel syndrome (IBS) pathophysiology.

Main Methods:

  • The RFGES utilized a rigorous methodology across 33 countries.
  • A comprehensive questionnaire, including the Rome IV Adult Diagnostic Questionnaire, was employed to diagnose 22 DGBI.
  • Supplemental questionnaires facilitated the analysis of factors associated with DGBI diagnoses.

Main Results:

  • The RFGES provides a robust dataset on the prevalence of 22 DGBI across diverse populations.
  • Reliable regional and global prevalence estimates for DGBI have been established.
  • The study facilitates deeper insights into the factors influencing DGBI.

Conclusions:

  • The RFGES represents a significant advancement in understanding the epidemiology of DGBI.
  • Findings from the RFGES will contribute to improved diagnostic and therapeutic strategies for DGBI.
  • This research lays the groundwork for future studies in neurogastroenterology and gut-brain interactions.