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Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...

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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

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Hear Me Out: Mitigating Cisplatin-Induced Ototoxicity

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¹Division of Medical Oncology, Mayo Clinic, Rochester, MN.

JCO Oncology Practice

|March 29, 2023

Summary

No abstract available in PubMed .

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