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Related Experiment Video

Updated: Aug 5, 2025

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

Microbial metabolites and immunotherapy: Basic rationale and clinical indications.

Larisa V Kovtonyuk¹, Kathy D McCoy¹

¹Department of Physiology & Pharmacology, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4A1, Canada.

Seminars in Immunology

|March 29, 2023

Summary

The gut microbiome influences host immunity and cancer immunotherapy outcomes. Microbial metabolites, like short-chain fatty acids (SCFA), modulate immune cells, enhancing cancer treatments.

Keywords:

Cancer immunotherapy Gut microbiome Microbial metabolites

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Area of Science:

Immunology
Microbiology
Oncology

Background:

The host microbiota plays a crucial role in shaping immunity.
Gut microbes possess metabolic capabilities vital for host physiology.
Microbial metabolites influence immune cell populations in health and disease.

Purpose of the Study:

To review recent findings on microbial metabolites in cancer immunotherapy.
To elucidate the mechanisms by which metabolites affect immunotherapy outcomes.

Main Methods:

Literature review of recent studies.
Analysis of research on microbial metabolites and immune responses.

Main Results:

Microbial metabolites, including short-chain fatty acids (SCFA), purine metabolites, cyclic dinucleotides, tryptophan derivatives, and secondary bile acids, significantly impact host immunity.
These metabolites can tailor the immune cell landscape, affecting both homeostasis and cancer immunotherapy.
Specific microbial metabolites are increasingly recognized for their role in enhancing the efficacy of immune checkpoint blockade therapies.

Conclusions:

Microbial metabolites are key orchestrators of immune responses relevant to cancer immunotherapy.
Understanding these metabolic interactions is crucial for improving cancer treatment strategies.
Further research into microbial metabolites offers potential for novel therapeutic approaches in oncology.